Denis Drygin Selected Research

silmitasertib

3/2016	Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells.
12/2013	Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
9/2012	Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells.
4/2012	CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy.
11/2011	Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer.
10/2011	Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer.
1/2011	Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.
12/2010	CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy.

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Denis Drygin Research Topics

Disease

24	Neoplasms (Cancer) 04/2023 - 10/2009
2	Neoplasm Metastasis (Metastasis) 01/2019 - 11/2011
2	Leukemia 01/2017 - 07/2012
2	Hematologic Neoplasms (Hematological Malignancy) 11/2016 - 07/2012
2	Carcinogenesis 11/2016 - 10/2009
2	Prostatic Neoplasms (Prostate Cancer) 11/2016 - 10/2011
2	Ovarian Neoplasms (Ovarian Cancer) 03/2016 - 04/2012
2	Lymphoma (Lymphomas) 01/2016 - 07/2012
2	Hypoxia (Hypoxemia) 04/2012 - 12/2010
2	Inflammation (Inflammations) 01/2012 - 11/2011
1	Osteosarcoma (Osteogenic Sarcoma) 04/2023
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Glucose Intolerance 01/2022
1	Leiomyosarcoma 01/2022
1	Ascites 03/2016
1	Glioblastoma (Glioblastoma Multiforme) 12/2013
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2012
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/2012
1	Rheumatoid Arthritis 11/2011
1	Inflammatory Breast Neoplasms 11/2011
1	Carcinoid Tumor (Carcinoid) 10/2009
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 10/2009
1	Carcinoma (Carcinomatosis) 01/2005
1	Necrosis 01/2004

Drug/Important Bio-Agent (IBA)

9	RNA Polymerase I (Polymerase I, RNA)IBA 04/2023 - 01/2010
8	CX 5461IBA 04/2023 - 02/2011
8	silmitasertibIBA 03/2016 - 12/2010
7	Casein Kinase II (Casein Kinase 2)IBA 03/2016 - 01/2011
4	Phosphotransferases (Kinase)IBA 11/2016 - 10/2009
4	Ribosomal DNA (rDNA)IBA 01/2016 - 10/2009
3	proto-oncogene proteins pimIBA 11/2016 - 02/2012
3	Proteins (Proteins, Gene)FDA Link 01/2016 - 10/2009
3	Carboxylic AcidsIBA 07/2012 - 01/2011
2	RNA (Ribonucleic Acid)IBA 11/2016 - 07/2012
2	Ribosomal RNAIBA 11/2016 - 02/2011
2	Small Interfering RNA (siRNA)IBA 03/2016 - 12/2013
2	Protein Kinases (Protein Kinase)IBA 03/2016 - 01/2010
2	CytokinesIBA 03/2016 - 11/2011
2	ErbB Receptors (EGF Receptor)IBA 09/2012 - 04/2012
2	Interleukin-6 (Interleukin 6)IBA 04/2012 - 11/2011
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Insulin (Novolin)FDA Link 01/2022
1	Estrogen Receptor alphaIBA 01/2019
1	CX-6258IBA 11/2016
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2016
1	Everolimus FDA Link 01/2016
1	Eukaryotic Initiation Factor-4EIBA 01/2016
1	Tumor Suppressor Protein p53IBA 03/2014
1	IntegrinsIBA 12/2013
1	Indicators and Reagents (Reagents)IBA 08/2013
1	Tyrosine Kinase InhibitorsIBA 09/2012
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 09/2012
1	EnzymesIBA 07/2012
1	benzo(c)fluoreneIBA 07/2012
1	Drug CombinationsIBA 04/2012
1	Cisplatin (Platino)FDA LinkGeneric 04/2012
1	Gemcitabine FDA Link 04/2012
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 11/2011
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 02/2011
1	Adenosine Triphosphate (ATP)IBA 01/2011
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2010
1	NucleolinIBA 10/2009
1	CX 3543IBA 10/2009
1	OligonucleotidesIBA 01/2005
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2005
1	Caspase 3 (Caspase-3)IBA 01/2004
1	ChromatinIBA 01/2004
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2004

Therapy/Procedure

6	Therapeutics 01/2016 - 04/2012
1	Drug Therapy (Chemotherapy) 01/2017
1	Castration 11/2016
1	Oral Administration 11/2016